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Using two separate drugs to lose weight naturally can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight-loss and the people who go through it you should err to the side of caution and permit the FDA do its job and demand some study be done so your public understands the side effects and hazards of the medications before we bring them. Keep in mind that drug companies are in business to earn money and that they would say almost anything to keep people on their own medications. Researchers discovered that participants investing in this drug for a year, dropped a few pounds within four weeks and have kept the weight off through the entire 56 weeks of the study. Contrave is often a combination in the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs which can be made up of several active ingredient, that might make them far better and safer. Combo-pilling could be the newest fad or better yet the newest into the future under scrutiny and for that reason it is just more publicly known lately, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills is becoming popular is the fact that as of right now there aren't long term prescription weightloss pills that have been approved by the FDA other than orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications although some people might of the combinations have been rejected or have yet to be approved by the FDA. Seizures are a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug may also raise blood pressure and pulse rate, and shouldn't be used in individuals with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure level and heartrate and must 't be used in patients with uncontrolled high blood pressure, as well as by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting mental performance) disease. Patients with a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes having a boxed warning to alert health care professionals and patients to the increased probability of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for smoking cessation. "This may be the first drug I'm aware of that targets both appetite and reward centres inside the brain," he explained.