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Combo-pilling will be the newest fad or in addition to this the newest ahead under scrutiny and so it is just more publicly known although in the past, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills is becoming popular will be the fact that as of right now there are no long term prescription diet pills that have been licensed by the FDA other than orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be approved by the FDA. Seizures can be a side effect with Contrave and really should not be taken in those with seizure disorders. The drug may also raise blood pressure level and heartbeat, and shouldn't be used in individuals with a history of cardiac arrest or stroke in the last six months. 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