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Using two separate drugs to shed weight can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with weight-loss and the people who go through it you should err assisting caution and allow the FDA do its job and demand some study be done so that the public understands the side effects and dangers of the medications before we drive them. Keep in mind that drug companies have been in business to generate income and that they would say anything to keep people on the medications. Researchers found out that participants taking this drug for the year, lost excess weight within one month and have kept the extra weight off throughout the 56 weeks in the study. Contrave is really a combination from the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs which might be made up of more than one active ingredient, that might make them more potent and safer. Combo-pilling may be the newest fad or even better the newest into the future under scrutiny and thus it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that utilizing a combination of pills is starting to become popular is the fact that by right now there are not any long term prescription slimming capsules that have been authorized by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations are already rejected or have yet to be approved by the FDA. Seizures certainly are a side effect with Contrave and mustn't be taken in people who have seizure disorders. The drug can also raise hypertension and heartbeat, and shouldn't be used in those with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise blood pressure levels and pulse rate and must not used in patients with uncontrolled high blood pressure, as well as by anyone with heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients which has a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert health care professionals and patients towards the increased chance of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking. From a psychiatric perspective, evidence suggests that the ordinary neural mechanism for goal-directed behavior has become hijacked through the addiction, and malfunctions so that its ordinary functions are exaggerated and fixated on its object. An object produces a stimulus and the person engages in a "goal-directed behavioral response" that produces a "natural high"(Bostwick & Bucci, 2008).