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Beta-blockers include Sectral (acebutolol), Tenormin (atenolol), Coreg (carvedilol), Lopressor and Tropol XL (metoprolol), Corgard (nadolol), Inderal (propranolol) and Blocadren (timolol). Potential explanations why single-drug therapies fail include the existence of coexisting conditions for example obesity, diabetes mellitus and kidney disease, non-adherence to therapy, isolated systolic hypertension and unpredictability of the blood pressure response. These include certain allergies (for example to other ACE inhibitors), angioedema, kidney disease, high levels of potassium inside blood, circulation system disease, loss of sodium, liver disease, severe dehydration, a collagen vascular disease, scleroderma, or lupus. Correcting a low profile vitamin B12 deficiency can result in a sudden improvement in mood. Liver problems that are possibly fatal, rarely occur, however they are possible.
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