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Using two separate drugs to lose weight can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight reduction and the individuals who go through it you should err to the side of caution and allow FDA do its job and demand some investigation be done so the public is aware of the side effects and perils associated with the medications before we take them. Keep in mind that drug companies are in business to earn money and that they would say everything to keep people on their own medications. Researchers found that participants investing in this drug for a year, lost weight within one month and have kept the extra weight off through the 56 weeks in the study. Contrave is a combination with the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs which might be made up of several active ingredient, which can make them far better and safer. Combo-pilling may be the newest fad or also the newest to come under scrutiny and thus it is just more publicly known recently, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills has become popular will be the fact that at the time of right now there aren't any long term prescription weight loss supplements that have been authorized by the FDA aside from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications however some of the combinations happen to be rejected or have yet to be licensed by the FDA. Seizures certainly are a side effect with Contrave and shouldn't be taken in those with seizure disorders. The drug also can raise blood pressure levels and heart rate, and must not be used in people who have a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure level and heart rate and must 't be used in patients with uncontrolled high hypertension, and also by a person with heart-related and cerebrovascular (circulation system dysfunction impacting mental performance) disease. Patients with a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert physicians and patients towards the increased risk of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stopping smoking. Other people who must avoid using Contrave are patients struggling with bulimia, anorexia nervosa, anyone using opiods, and patients undergoing an 'abrupt discontinuation of alcohol, benzodiazepines, barbiturates and antiepileptic drugs.' Lastly Concave shouldn't be prescribed for girls who are pregnant or trying to become pregnant.