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Using two separate drugs to lose weight can be very effective you can find combinations while watching FDA now awaiting approval. When dealing with weight reduction and the people who go through it one should err along the side of caution and allow FDA do its job and demand some investigation be done so that the public understands the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies are in business to generate money and that they would say everything to keep people on their own medications. Researchers found out that participants taking this drug for the year, lost weight within one month and have kept the load off through the entire 56 weeks with the study. Contrave is often a combination in the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs that are made up of multiple active ingredient, that might make them far better and safer. Combo-pilling may be the newest fad or better yet the newest into the future under scrutiny and therefore it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that utilizing a combination of pills is starting to become popular may be the fact that at the time of right now there aren't any long term prescription weight loss supplements that have been approved by the FDA besides orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations are actually rejected or have yet to be authorized by the FDA. Seizures really are a side effect with Contrave and must not be taken in individuals with seizure disorders. The drug also can raise blood pressure level and heart rate, and must not be used in people who have a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure level and heartrate and must not used in patients with uncontrolled high blood pressure, in addition to by anyone with heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients having a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes with a boxed warning to alert health care professionals and patients for the increased risk of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stopping smoking. "There were no indications of depression or suicidal thoughts in trial participants," said Fujioka.